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Serum Retinol Binding Protein 4 (human recombinant)
Cayman Chemical Item Number 10007818
Description
Source:recombinant His-tagged protein purified from E. coli · Mr:~21 kDa · Human serum retinol binding protein 4 (sRBP4) binds to one equivalent of vitamin A and is one of the major retinol carriers found in the blood of mammals.1↗,2↗ Human sRBP4 is a monomeric 21 kDa β-sheet-rich protein that contains three disulfide bonds and belongs to the lipocalin protein family.3↗ In plasma, sRBP4 typically forms a 1:1 complex with the 55 kDa tetrameric protein transthyretin (TTR) which prevents RBP from being removed from the plasma by glomerular filtration.4↗ Recent studies have shown that sRBP4 is an adipocyte-derived “signal” that may contribute to the pathogenesis of type 2 diabetes.5↗,6↗ Elevation of sRBP4 causes systemic insulin resistance, whereas reduced serum concentrations of sRBP4 improves insulin action.5↗,7↗,8↗ Cayman’s human recombinant sRBP4 contains a C-terminal hexahistidine tag. The purified protein was characterized for its retinol binding activity.
Synonyms sRBP4 RBP4
Formulation A solution in 50 mM sodium phosphate, pH 8.2, containing 100 mM sodium chloride and 20% glycerol
Purity ≥95%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere |