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Cayman Chemical Item Number 10007782
Ins(3,4,5,6)-P4; 3,4,5,6-IP4
Description
D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt) (Ins(3,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. It almost completely inhibits calcium-activated chloride channels at a concentration of 8-10 µM.1↗ Related inositol oligophosphates Ins(1,3,4,5)-P4, Ins(1,3,4,6)-P4, Ins(1,4,5,6)-P4, and Ins(1,3,4,5,6)-P5 do not inhibit the calcium channel at concentrations up to 100 µM.1↗ Ins(1,3,4)P3-mediated inhibition of Ins(3,4,5,6)-P4 1-kinase increases the cellular level of Ins(3,4,5,6)-P4, thus regulating channel inhibition.2↗ Ins(3,4,5,6)-P4 was found to be inactive when analyzed for Ca2+-releasing potency in Xenopus oocytes.3↗
Synonyms Ins(3,4,5,6)-P4
3,4,5,6-IP4
Formal Name D-myo-inositol-3,4,5,6-tetra(hydrogen phosphate), tetrasodium salt
Molecular Formula C6H12O18P4 · 4Na
Formula Weight 588.0
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O[C@H]1[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H]1O.[Na+].[Na+].[Na+].[Na+]
InCHI Code 1S/C6H16O18P4.4Na/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11;;;;/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);;;;/q;4*+1/p-4/t1-,2+,3?,4?,5?,6?;;;;
InCHI Key DZJJWPAQUIBBLR-GUBBRYCUSA-J |