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D-myo-Inositol-2,4,5-triphosphate (sodium salt)
Cayman Chemical Item Number 10007779
Description
The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals.1↗,2↗ The most studied InsP, D-myo-Inositol-2,4,5-triphosphate (sodium salt) (Ins(1,4,5)P3), more commonly referred to as IP3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.3↗,4↗ Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.4↗,5↗ Ins(2,4,5)P3 is a metabolically stable analog of Ins(1,4,5)P3 that is commonly used to study Ca2+ signaling pathways. Ins(2,4,5)P3 acts as a partial agonist at rat hepatic IP3 receptors, exhibiting 65% of the maximal Ca2+ response obtained with Ins(1,4,5)P3.6↗
Synonyms
Ins(2,4,5)P3 (sodium salt)
2,4,5-IP3 (sodium salt)
Formal Name D-myo-inositol-2,4,5-tris(hydrogen phosphate), trisodium salt
Molecular Formula C6H12O15P3 · 3Na
Formula Weight 486.0
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+]
InCHI Code 1S/C6H15O15P3.3Na/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t1-,2-,3-,4?,5?,6?;;;/m0.../s1
InCHI Key ZVCVTWVBDIPWPZ-UIEDNGEDSA-K |