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19(R)-HETE
Cayman Chemical Item Number 10007767
Description 19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively.1↗ Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels.2↗ However, 19(R)-HETE at 1 µM completely blocks 20-HETE-induced vasoconstriction of renal arterioles, whereas 19(S)-HETE remains inactive.3↗,4↗
Formal Name 19R-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
CAS Number 115461-39-7
Molecular Formula C20H32O3
Formula Weight 320.5
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES CC(O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O
InCHI Code 1S/C20H32O3/c1-19(21)17-15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-18-20(22)23/h3-6,9-12,19,21H,2,7-8,13-18H2,1H3,(H,22,23)/b5-3-,6-4-,11-9-,12-10-/t19-/m1/s1
InCHI Key XFUXZHQUWPFWPR-PCYSVGMOSA-N |