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HMB-Val-Ser-Leu-VE
Cayman Chemical Item Number 10007713
Description
The 20S proteasome is a 700 kDa, multi-subunit cylinder-shaped protein that functions as the central protease within the ubiquitin-proteasome pathway utilized by cells for the regulated degradation of proteins.1↗,2↗ HMB-val-ser-leu-VE is a tripeptide bearing a C-terminal vinyl ester which acts as a potent, selective inhibitor of the trypsin-like activity of the 20S proteasome. It inhibits the tryptic-like, chymotryptic-like, and post acidic activities of the purified 20S proteasome with IC50 values of 0.33 µM, >10 µM, and >10 µM, respectively.3↗ HMB-val-ser-leu-VE is cell permeable and stable (t½ ~6 hours) in in vitro assays.
Formal Name N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-butenyl]-L-serinamide
CAS Number 862891-04-1
Molecular Formula C26H39N3O7
Formula Weight 505.6
Formulation A crystalline solid
Purity ≥98%
λmax 210 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES OC1=CC=CC(C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)/C=C/C(OCC)=O)=O)=O)=O)=C1C
InCHI Code 1S/C26H39N3O7/c1-7-36-22(32)12-11-18(13-15(2)3)27-25(34)20(14-30)28-26(35)23(16(4)5)29-24(33)19-9-8-10-21(31)17(19)6/h8-12,15-16,18,20,23,30-31H,7,13-14H2,1-6H3,(H,27,34)(H,28,35)(H,29,33)/b12-11+/t18-,20+,23+/m1/s1
InCHI Key YQKMRGLFGXKLJC-VOSPOJDESA-N |