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PtdIns-(1,2-dipalmitoyl) (ammonium salt)Exclusive
Cayman Chemical Item Number 10007710
Description
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1↗,2↗ PtdIns-(1,2-dipalmitoyl) is a synthetic analog of natural PtdIns featuring C16:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
Synonyms
Phosphatidylinositol C-16
DPPI
Formal Name 1-(1,2-dihexadecanoylphosphatidyl)inositol, monoammonium salt
CAS Number 34290-57-8
Molecular Formula C41H78O13P • NH4
Formula Weight 828.1
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](OP([O-])(OC[C@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O)[C@@H]1O.[NH4+]
InCHI Code 1S/C41H79O13P.H3N/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(42)51-31-33(32-52-55(49,50)54-41-39(47)37(45)36(44)38(46)40(41)48)53-35(43)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h33,36-41,44-48H,3-32H2,1-2H3,(H,49,50);1H3/t33-,36-,37-,38+,39-,
InCHI Key MRDHBHKPDFRCJQ-VGFLHHNXSA-N |