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N-Palmitoyl Dopamine
Cayman Chemical Item Number 10007697
Description
Several different fatty acyl dopamine analogs, such as N-arachidonoyl dopamine (NADA), N-oleoyl dopamine (ODA) and N-palmitoyl dopamine (PALDA), have been isolated and characterized from bovine brain.1↗,2↗ Structurally, PALDA is the amide of palmitic acid and dopamine and is therefore a “hybrid” analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. Unlike NADA and ODA, PALDA is nearly inactive as a vanilloid receptor 1 (VR1) ligand and fails to elicit hyperalgesic or nocifensive responses in vivo.2↗ However, PALDA exhibits an “entourage” effect at concentrations of 0.1-10 µM by potentiating the VR1-mediated effects of NADA and anandamide.3↗
Synonyms PALDA
Formal Name N-[2-(3,4-dihydroxyphenyl)ethyl]-hexadecanamide
CAS Number 136181-87-8
Molecular Formula C24H41NO3
Formula Weight 391.6
Formulation A solution in ethanol
Purity >98%
λmax 204, 283 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCCCCCCCCCC(=O)NCCc1ccc(O)c(O)c1
InCHI Code 1S/C24H41NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(28)25-19-18-21-16-17-22(26)23(27)20-21/h16-17,20,26-27H,2-15,18-19H2,1H3,(H,25,28)
InCHI Key TWJJFOWLTIEYFO-UHFFFAOYSA-N |