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L-Biopterin
Cayman Chemical Item Number 10007662
Description
L-Biopterin is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs).1↗ L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.2↗
Synonyms L-erythro-Biopterin
NSC 339699
Formal Name 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone
CAS Number 22150-76-1
Molecular Formula C9H11N5O3
Formula Weight 237.2
Formulation A crystalline solid
Purity >98%
λmax 276, 348 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES NC(N=C1C2=NC([C@@H](O)[C@@H](O)C)=CN1[H])=NC2=O
InCHI Code 1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h2-3,6,15-16H,1H3,(H3,10,11,13,14,17)/t3-,6-/m0/s1
InCHI Key LHQIJBMDNUYRAM-DZSWIPIPSA-N |