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CAY10486
Cayman Chemical Item Number 10006452
Description Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.1↗,2↗ CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 of approximately 60 µM.3↗ It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 µM.3↗
Synonyms 4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide
Formal Name N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester
CAS Number 615264-52-3
Molecular Formula C19H19NO4
Formula Weight 325.4
Formulation A crystalline solid
Purity ≥98%
λmax 210, 226, 311 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O=C(N[C@@H](CC1=CC=CC=C1)C(OC)=O)/C=C/C2=CC=C(O)C=C2
InCHI Code 1S/C19H19NO4/c1-24-19(23)17(13-15-5-3-2-4-6-15)20-18(22)12-9-14-7-10-16(21)11-8-14/h2-12,17,21H,13H2,1H3,(H,20,22)/b12-9+
InCHI Key ATJBWQGWPYQIAR-FMIVXFBMSA-N |