|
HIF-1α (C-Term) Polyclonal Antibody
Cayman Chemical Item Number 10006421
Description
Antigen:HIF-1α amino acids 809-826 · Host:rabbit · Application(s):(+) WB; (−) ICC and IP · Hypoxia inducible factor-1α (HIF-1α) is a transcription factor that accumulates under low-oxygen conditions.1↗,2↗ Following hypoxic stimulus and cytoplasmic accumulation, HIF-1α migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival.2↗,3↗,4↗,5↗,6↗ HIF-1α is an endothelial PAS domain protein 1 (EPAS-1) family member with phosphorylation dependent activities.7↗,8↗ Cayman Chemical’s HIF-1α polyclonal antibody can be used for WB analysis for HIF-1α on samples from human, mouse, and simian. It is not suitable for ICC or IP. Other applications for use of this antibody have not yet been tested.
Synonyms Hypoxia Inducible Factor-1α
Formal Name
Formulation Peptide affinity-purified IgG lyophilized from TBS, pH 7.4
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Specificity Human HIF-1α Mouse HIF-1α Simian HIF-1α |