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Adipose Triglyceride Lipase Polyclonal Antibody
Cayman Chemical Item Number 10006409
Description Antigen:human adipose triglyceride lipase (ATGL) amino acids 382-400 (KRKLGRHLPSRLPEQVELR) · Host:rabbit · Application(s):WB and IHC (paraffin-embedded sections); other applications not tested · Triglycerides are the most efficient form of energy storage in mammalian adipose tissue during times of caloric excess. ATGL is one of the key enzymes involved in the mobilization of fatty acids from triglyceride stores in adipose tissue, catalyzing the conversion of triacylglycerols to diacylglycerols.1↗ Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity, and thus may be a potential drug target for the diabetic pathology.1↗ ATGL mRNA is detected in a wide range of tissues including adipose, lung, skeletal muscle, testis, heart, brain, and kidney, with adipose tissue expressing the highest level.2↗ Human ATGL is 504 amino acids in length with an estimated molecular weight of 55.2 kDa. Cayman’s ATGL polyclonal antibody detects the enzyme at 56 kDa by western blot from tissues and cells such as brown fat, liver, mouse macrophages, and HepG2 cells.
Synonyms PNPLA2 ATGL Desnutrin
Phospholipase A2ζ
Formal Name
Formulation Peptide affinity-purified IgG, lyophilized from TBS pH 7.4
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Specificity Human ATGL Mouse ATGL Rat ATGL |