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CAY10462
Cayman Chemical Item Number 10006400
Description
20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family.1↗,2↗ Alkylaryl imidazoles have been shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis.3↗ CAY10462 is the hydrochloride salt of CAY10434 and selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 of 8.8 nM when tested in human renal microsomes.4↗ CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.
Formal Name 6-[4-(1H-imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride
CAS Number 502656-68-0
Molecular Formula C17H25N3O • 2HCl
Formula Weight360.3
Formulation A crystalline solid
Purity≥98%
λmax 202, 246 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CN(C)CCCCCCOC1=CC=C(N2C=CN=C2)C=C1.Cl.Cl
InCHI Code 1S/C17H25N3O.2ClH/c1-19(2)12-5-3-4-6-14-21-17-9-7-16(8-10-17)20-13-11-18-15-20;;/h7-11,13,15H,3-6,12,14H2,1-2H3;2*1H
InCHI Key SRCWAJONAASSNJ-UHFFFAOYSA-N |