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S1P3 Polyclonal Antibody
Cayman Chemical Item Number 10006373
Description
Antigen:human S1P3 amino acids 12-25 (VRGNETLREHYQYV) · Host:rabbit · Application(s):ICC and WB · Sphingosine-1-phosphate (S1P) exerts its activity by binding to five distinct G-protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.1↗,2↗ S1P3 couples to Gi/o-ERK, Gq-PLC, and G12/13-Rho axes to mediate S1P-induced cell proliferation, survival, migration, and related signaling events.1↗,2↗,3↗ S1P3 is widely expressed in various tissues, suggesting diverse physiological functions of this receptor.4↗ The human and mouse S1P3 have 378 amino acids with an estimated molecular weight of 42 kDa. Glycosylation at the N-terminal extracellular domain may cause the protein to migrate at different positions in SDS-PAGE. Cayman’s S1P3 polyclonal antibody detects the receptor at 47 kDa using samples from human cerebral cortex. Liver and heart tissues display 2-3 bands between 40-50 kDa, possibly due to different degree of glycosylation.
Synonyms EDG-3 S1PR3 Sphingosine-1-phosphate Receptor 3
Formal Name
Formulation Peptide affinity-purified IgG yophilized from TBS, pH 7.4, containing 5 mg/ml BSA
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Specificity
Human S1P3
Mouse S1P3
Rat S1P3 |