|
Endocrinology (358)
Metabolism (187)
Description
Peptide sequence:mouse melanocortin-4 (MC4R) receptor amino acids 21-33 (YGLHSNASESLGK) · To be used in conjunction with Cayman’s MC4R polyclonal antibody (Catalog No. 10006355) to block protein-antibody complex formation during immunochemical analysis of melanocortin-4 · Melanocortins are known to exert a broad array of physiological actions including 'melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis'.1↗ These actions are mediated (differentially or concurrently) in part by a family of G-protein coupled receptors, the melanocortin receptors 1-5 (MC1R-MC5R). Melanocortin-4 receptor (MC4R) was first cloned in 1993 with transcripts expressed primarily in the brain.2↗ Genetic studies of mice and humans have established a critical role of MC4R in appetite regulation.3↗ Heterozygous mutations in MC4R account for 1-6% of severe cases of human obesity. Thus, MC4R has been a prime target for therapeutic intervention in obesity.4↗ All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 37 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE.5↗ Cayman’s MC4R polyclonal antibody mainly detects an unglycosylated protein at 37 kDa and a glycosylated protein at 55 kDa.
Synonyms MC4R
Formal Name
Formulation 200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere |