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D-NMAPPDExclusive
Cayman Chemical Item Number 10006305
Description
Ceramidase acts in normal cells to keep ceramide concentrations low and maintain cell viability. The inhibition of ceramidase in both malignant and non-cancerous cells leads to apoptosis.1↗,2↗ D-NMAPPD is a potent ceramidase inhibitor that induces apoptosis in human colorectal cancer, keratinocyte, and melanoma cell lines.3↗,4↗ D-NMAPPD produces approximately 50% cell non-viability at 10 µM and >80% cell death at 100 µM.4↗
Synonyms (1R,2R)-B13 CAY10466
Formal Name
N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-tetradecanamide
CAS Number 35922-06-6
Molecular Formula C23H38N2O5
Formula Weight 422.6
Formulation A crystalline solid
Purity≥98%
λmax 202, 275 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES OC[C@@H](N([H])C(CCCCCCCCCCCCC)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1
InCHI Code 1S/C23H38N2O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-22(27)24-21(18-26)23(28)19-14-16-20(17-15-19)25(29)30/h14-17,21,23,26,28H,2-13,18H2,1H3,(H,24,27)/t21-,23-/m1/s1
InCHI Key XUSDVLHKNBOGJY-FYYLOGMGSA-N |