|
FTY720
Cayman Chemical Item Number 10006292
Description
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1↗ FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5).2↗ Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.3↗ FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc1 and inhibits cytosolic phospholipase A2 activity.4↗,5↗
Synonyms FTY720 (hydrochloride) Fingolimod (hydrochloride)
Formal Name 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride
CAS Number 162359-56-0
Molecular Formula C19H33NO2 · HCl
Formula Weight 343.9
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1.Cl
InCHI Code 1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InCHI Key SWZTYAVBMYWFGS-UHFFFAOYSA-N |