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Pentafluorobenzenesulfonyl fluorescein
Cayman Chemical Item Number 10005983
Description
Reactive oxygen species (ROS) play important roles in the initiation and progression of many disease processes. Most fluorescent probes for ROS detection, such as 2,7-dichlorofluorescein (DCFH), function by an oxidative mechanism and are useful for total oxidant detection but are not selective for hydrogen peroxide specifically.1↗ Pentafluorobenzenesulfonyl fluorescein is a fluorescent probe that functions by a nonoxidative mechanism. It fluoresces upon perhydrolysis of the sulfonyl linkage, and is selective for hydrogen peroxide over hydroxyl radical, tert-butyl hydroperoxide, superoxide anion, singlet oxygen, and nitrates. Pentafluorobenzenesulfonyl fluorescein can be used as a probe for hydrogen peroxide in whole cell systems.1↗
1 Maeda, H., Fukuyasu, Y., Yoshida, S., et al. Fluorescent probes for hydrogen peroxide based on a non-oxidative mechanism. Angew Chem Int Ed 43 2389-2391 (2004).
Formal Name 6’-hydroxy-3-oxospiro[isobenzofuran-1(3H),9’-[9H]xanthen]-3’-yl ester, pentafluorobenzenesulfonic acid
CAS Number 728912-45-6
Molecular Formula C26H11F5O7S
Formula Weight 562.4
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES FC1=C(F)C(F)=C(F)C(F)=C1S(OC2=CC=C(C3(OC(C4=CC=CC=C43)=O)C(C=CC(O)=C5)=C5O6)C6=C2)(=O)=O
InCHI Code 1S/C26H11F5O7S/c27-19-20(28)22(30)24(23(31)21(19)29)39(34,35)38-12-6-8-16-18(10-12)36-17-9-11(32)5-7-15(17)26(16)14-4-2-1-3-13(14)25(33)37-26/h1-10,32H
InCHI Key UIBLLPHZQUTIBL-UHFFFAOYSA-N |