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Cerulenin
Cayman Chemical Item Number 10005647
Description
A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines,1↗ an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway.2↗ Cerulenin also leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.3↗
Formal Name 2R,3S-epoxy-4-oxo-7,10-dodecadienamide
CAS Number 17397-89-6
Molecular Formula C12H17NO3
Formula Weight 223.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
InCHI Code 1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1
InCHI Key GVEZIHKRYBHEFX-NQQPLRFYSA-N |