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Lysophospholipase D Polyclonal Antibody
Cayman Chemical Item Number 10005375
Description
Antigen:rat lysophospholipase D (lysoPLD) amino acids 573-588 (KNKLEELNKRLHTKGS) · Host:rabbit · Application(s):ICC and WB · Lysophosphatidic acid (LPA) is an extracellular signaling lipid that evokes multiple biological functions including induction of platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and chemotaxis.1↗ lysoPLD was first discovered in 1999 as the enzyme responsible for generating LPA from lysophosphatidylcholine (LPC).2↗ It was later revealed to be identical to an autocrine motility factor, autotaxin (ATX), which plays a role in tumor progression and metastasis.3↗,4↗ lysoPLD/ATX mRNA is widely expressed with highest levels found in brain, ovary, lung, intestine, and testis.5↗,6↗ Rat lysoPLD is composed of 885 amino acids with an estimated molecular weight of 101 kDa. The protein is reported to be heavily glycosylated and thus its apparent size on SDS-PAGE may be run as high as 125 kDa. Useful positive controls include cerebrospinal fluid, mouse ascites or seminal plasma.
Synonyms
ENPP2
lysoPLD
Autotaxin
Formal Name
Formulation Peptide affinity-purified IgG
Stability 3 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Specificity
Human lysoPLD
Mouse lysoPLD
Rat lysoLPD |