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LPA1 Polyclonal Antibody
Cayman Chemical Item Number 10005280
Description
Antigen:human lysophosphatidic acid 1 (LPA1) amino acids 342-359 (DRSASSLNHTILAGVHSN) · Host:rabbit · Application(s):WB and ICC; other applications not tested · LPA1 (also known as EDG-2) is one of four known LPA receptors (LPA1-4).1↗ LPA1-3 are part a family of G protein-coupled receptors that share identity to the sphingosine-1-phosphate receptors (S1P1-5).2↗ LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13 to induce a range of cellular responses including activation of phospholipase C, multiple kinases, the serum response element and cell proliferation.3↗,4↗ LPA1 mRNA is detected a wide range of tissues and cells including brain, heart, small intestine, spleen, testis, kidney, HeLa cells, and A549 cells.5↗,6↗ Mouse and human LPA1 have 364 amino acids with an estimated molecular weight of 41 kDa.4↗ Cayman’s LPA1 polyclonal antibody detects the protein from several species from 43-50 kDa, suggesting heterogeneous LPA1 post-translational modifications in distinct cells.
Synonyms LPA Receptor 1
LPAR1
Vzg-1
EDG-2
Formal Name
Formulation Peptide affinity-purified IgG
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Specificity Bovine LPA1
Human LPA1
Mouse LPA1
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