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(±)-C75
Cayman Chemical Item Number 10005270
Description
Inhibition of fatty acid synthase (FAS) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.1↗ (±)-C75 is a more stable inhibitor of FAS than cerulenin that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.2↗ (±)-C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway.3↗
Formal Name tetrahydro-4-methylene-2R-octyl-5-oxo-3S-furancarboxylic acid
CAS Number 191282-48-1
Molecular Formula C14H22O4
Formula Weight 254.3
Formulation A crystalline solid
Purity ≥98%
λmax 207 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCC[C@H]1OC(=O)C(=C)C1C(=O)O
InCHI Code 1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12?/m1/s1
InCHI Key VCWLZDVWHQVAJU-JHJMLUEUSA-N |