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TOFA
Cayman Chemical Item Number 10005263
Description
Inhibition of fatty acid synthase (FAS) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.1↗ TOFA is an inhibitor of fatty acid synthesis acting one step earlier in the metabolic pathway, blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC).2↗ Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of radiolabeled acetate into palmitate. However, TOFA reduces malonyl-CoA levels rather than elevating them, and TOFA is relatively non-toxic to various cancer cell lines. TOFA also attenuates the inhibition of feeding observed when FAS inhibitors such as cerulenin and C75 are administered to obese ob/ob mice.
Synonyms
5-(Tetradecyloxy)-2-furoic Acid
RMI 14514
Formal Name 5-(tetradecyloxy)-2-furancarboxylic acid
CAS Number 54857-86-2
Molecular Formula C19H32O4
Formula Weight 324.5
Formulation A crystalline solid
Purity ≥98%
λmax 278 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCCCCCCCCOc1ccc(o1)C(=O)O
InCHI Code 1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
InCHI Key CZRCFAOMWRAFIC-UHFFFAOYSA-N |