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Serine Palmitoyltransferase Polyclonal Antibody
Cayman Chemical Item Number 10005260
Description
Antigen:human serine palmitoyltransferase subunit SPT2 amino acids 548-562 · Host:rabbit · Application(s):IHC (formalin-fixed paraffin-embedded sections) and WB · Sphingolipids play essential roles in various cellular events, including proliferation, differentiation, senescence, apoptosis, and inflammatory responses.1↗ Serine palmitoyltransferase (SPT) is the initial and rate-limiting enzyme in the de novo sphingolipid biosynthesis, and thus regulates the level of sphingolipids in cells.2↗ Immunohistochemical study revealed widespread distribution of the enzyme with most strong expression in brain and digestive tract.3↗ Two subunits, SPT1 and SPT2 at a stoichiometry of 1:1, are involved in the enzymatic activity of SPT.4↗ Cayman Chemical’s serine palmitoyltransferase polyclonal antibody recognizes SPT2, the long chain subunit of the enzyme. The antibody stains mainly cell nuclei and occasionally both cell nuclei and cytoplasm in formalin-fixed, paraffin-embedded rat brain tissue. The nuclear localization of SPT2 may suggest that SPT2 associates with another nuclear protein or is modified and transported to the nucleus.2↗
Synonyms SPT
Serine-palmitoyl-CoA transferase, long chain base subunit 2
Formal Name
Formulation Peptide affinity-purified IgG
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Specificity Human serine palmitoyltransferase
Mouse serine palmitoyltransferase
Rat serine palmitoyltransferase
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