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2,3-DCPE (hydrochloride)
Cayman Chemical Item Number 10005229
Description
2,3-DCPE is a proapoptotic compound with selectivity for cancer cells versus normal human cells. It induces apoptosis in vitro in various cancer cell lines (IC50s = 0.89-2.69 µM) more effectively than in normal human fibroblasts (IC50 = 12.6 µM). 2,3-DCPE down-regulates Bcl-XL, however forced overexpression of Bcl-XL is sufficient to block 2,3-DCPE apoptosis induction.1↗ 2,3-DCPE can induce S-phase arrest, upregulate p21, and activate ERK.2↗
Formal Name 2-[[3-(2,3-dichlorophenoxy)propyl]amino]-ethanol, monohydrochloride
CAS Number 1009555-55-8
Molecular Formula C11H15Cl2NO2 • HCl
Formula Weight 300.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES ClC1=C(Cl)C(OCCCN([H])CCO)=CC=C1.Cl
InCHI Code 1S/C11H15Cl2NO2.ClH/c12-9-3-1-4-10(11(9)13)16-8-2-5-14-6-7-15;/h1,3-4,14-15H,2,5-8H2;1H
InCHI Key GFCJFYSIPRIHKT-UHFFFAOYSA-N |