Functional Aspects:Alpha parvalbumin is a water-soluble calcium-binding protein found in select fast-spiking inhibitory GABAergic interneurons with a calcium buffering capacity. Neurons that contain parvalbumin seem to be resistant to ischaemia, epilepsy and N-methyl-D-aspartate receptor agonists due to their ability to buffer increases in intracellular albumin. Reduced expression of alpha parvalbumin has been reported in Purkinje cells in cases of spinocerebellar ataxia-1. This antibody is specific for the alpha form of parvalbumin.
