The Vector® M.O.M.™ Immunodetection Kits are specifically designed to localize mouse primary antibodies on mouse tissues. The major problem with using mouse primary antibodies on mouse tissues in immunohistochemistry is the inability of the anti-mouse secondary antibody to distinguish between the mouse primary antibody and endogenous mouse immunoglobulins in the tissue. This can result in high background staining which obscures specific staining. This problem can be essentially eliminated by using a Vector® M.O.M.™ Immunodetection Kit which includes a proprietary M.O.M.™ Mouse Ig Blocking Reagent with a specialized M.O.M.™ Biotinylated Anti-Mouse Ig to significantly reduce undesired binding of the secondary antibody to endogenous tissue immunoglobulin.