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APP Antibody
Product Overview
Antibody Target: APP
Alternative Name: amyloid-b-peptide, amyloid beta peptide, Amyloid beta A4 protein, Alzheimer disease amyloid protein, ABPP, APPI, Cerebral vascular amyloid peptide,
Host: Rabbit
Antibody Type: Polyclonal
Isotype: Rabbit IgG
Immunogen: Synthetic peptide from human APP
Accession#: P05067
Gene ID: 351
Appearance: Colorless liquid
Concentration: 0.5 mg/ml
Formulation: 100 µg (0.5 mg/ml) immunoaffinity purified rabbit anti-APP polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Purification: Affinity purified
Species Reactivity: human, mouse, rat
Application: Western blot, Immunohistochemistry
Application & Usage: Western blot analysis (1-4 µg/ml) and Immunohistochemistry (2-10 ug/ml). However, the optimal conditions should be determined individually. Murine and rat brain tissues can be used as positive controls.
Storage Temp.: -20 °C
Shipping: gel pack
Background Descriptions: Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The β-amyloid protein precursor (APP) is cleaved by β-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-β peptide, which is deposited in the brains of all suffers of Alzheimer’s disease.
Handling: The antibody solution should be gently mixed before use.
Usage: For Research Use Only! Not to be used in humans. |